I'd have to imagine as long as the casters were rated for the weight of the machine (say the machine is 2000 pounds; seems like four 500 pound casters would be good enough). I don't think you'll want to leave the machine on the wheels though. there are casters that have integrated feet (check out the link below), it seems like those would be the ones to get.
Here's a thread on CNC Zone about some casters that the OP apparently really likes:
Best Workbench Casters. Period! I haven't read that thread in a while, but perhaps it'll give you some ideas on what to look for in a caster. By the way, those are rated for 125 pounds, so I guess a one ton machine would need eight.
Another idea is to have a base with slots in it that will allow you to use a forklift or a
pallet jack when you need to move it. Someone mentioned this method in the micRo thread a few months ago. Lemme see if I can find the post...
Here it is:
http://www.lumenlab.com/forums/index.php?s...st&p=311155