QUOTE (Hirudin @ Apr 7 2009, 07:18 PM)

T-Slots are nice, but how would you feel about a regularly spaced pattern of tapped holes? The micRo base could be machined by the micRo while attached to the micRo. So, you could make any pattern you want, but 1" by 1" spacing of 10-32 tapped holes seems to work for a lot of people. Heck, you could also just make a new set of mounting holes for each new project that requires it.
The grid of holes approach is much better than t-slots in my opinion.
I have a small fixture plate for my micro mill that uses this approach but alternates rows of threaded and unthreaded holes every .5" This gives the 1" x 1" spacing of threaded holes you mention above and also a similar grid of unthreaded holes used to place dowel pins. The pins are great for locating a part but also can be used with pairs of wedges to secure a part.
One cool thing about the threaded holes is using a socket head cap screw (SHCS) as the fulcrum for a strap clamp. You screw the SHCS in to match the height of the workpiece and bolt a strap clamp across the SHCS head and the workpiece, securing the clamp with another SHCS in the next threaded hole. The SHCS fulcrum is much easier than using the typical stepped blocks.
Or get fancy and add a threaded hole to the clamps like these:

Here's an example of a mini-mill fixture plate:
http://www.fignoggle.com/plans/figNoggle_X2FixturePlate.pdf